AustralieFrV1, Main, Exploration, bibRecord, 00B193

Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and ccr5 modulation

Identifieur interne : 00B193 ( Main/Exploration ); précédent : 00B192; suivant : 00B194

Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and ccr5 modulation

Auteurs : Juliana Croitoru-Lamoury [France, Australie] ; Gilles J. Guillemin [Australie] ; Francois D. Boussin [France] ; Barbara Mognetti [France] ; Laure I. Gigout [France] ; Arnaud Cheret [France] ; Bruno Vaslin [France] ; Roger Le Grand [France] ; Bruce J. Brew [Australie] ; Dominique Dormont [France]

Source :

Glia : (New York, NY) [ 0894-1491 ] ; 2003.

RBID : Pascal:03-0206041

Descripteurs français

Pascal (Inist)
- Chimiokine, Expression génique, Récepteur biologique, Astrocyte, Singe, Facteur nécrose tumorale α, Interféron gamma, Homme.
Wicri :
- topic : Singe, Homme.

English descriptors

KwdEn :
- Astrocyte, Biological receptor, Chemokine, Gamma interferon, Gene expression, Human, Monkey, Tumor necrosis factor α.

Abstract

Chemokines are key mediators of the selective migration of leukocytes that occurs in neurodegenerative diseases and related inflammatory processes. Astrocytes, the most abundant cell type in the CNS, have an active role in brain inflammation. To ascertain the role of astrocytes during neuropathological processes, we have investigated in two models of primary cells (human fetal and simian adult astrocytes) the repertoire of chemokines and their receptors expressed in response to inflammatory stimuli. We demonstrated that, in the absence of any stimulation, human fetal and simian adult astrocytes express mRNA for receptors APJ, BOB/GPR15, Bonzo/CXCR6, CCR2, CCR3, CCR5, CCR8, ChemR23, CXCR3/GPR9, CXCR4, GPR1, and V28/CX3CR1. Moreover, TNFa and IL-1β significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models. Furthermore, TNFa and IFNγ act synergistically to induce expression of the major coreceptors for HIV infection, CXCR4 and CCR5, at both the mRNA and protein levels in human and simian astrocytes, whereas CCR3 expression was not affected by cytokine treatment. Finally, TNFα/IFNγ was the most significant cytokine combination in leading to a pronounced upregulation in a comparable, time-dependent manner of the production of chemokines IP-10/CXCL10, RANTES/CCL5, MIG/CXCL9, MCP-1/CCL2, and IL-8/CXCL8. In , these data suggest that astrocytes serve as an important source of chemokines under the dependence of a complex cytokine regulation, and TNFa and IFNγ are important modulators of chemokines and chemokine receptor expression in human as well as simian astrocytes. Finally, with the conditions we used, there was no difference between species or age of tissue.

Affiliations:

Australie, France

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 005395
to stream PascalFrancis, to step Curation: 000D31
to stream PascalFrancis, to step Checkpoint: 004F75
to stream Main, to step Merge: 00BF60
to stream Main, to step Curation: 00B193

Le document en format XML

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<front><div type="abstract" xml:lang="en">Chemokines are key mediators of the selective migration of leukocytes that occurs in neurodegenerative diseases and related inflammatory processes. Astrocytes, the most abundant cell type in the CNS, have an active role in brain inflammation. To ascertain the role of astrocytes during neuropathological processes, we have investigated in two models of primary cells (human fetal and simian adult astrocytes) the repertoire of chemokines and their receptors expressed in response to inflammatory stimuli. We demonstrated that, in the absence of any stimulation, human fetal and simian adult astrocytes express mRNA for receptors APJ, BOB/GPR15, Bonzo/CXCR6, CCR2, CCR3, CCR5, CCR8, ChemR23, CXCR3/GPR9, CXCR4, GPR1, and V28/CX3CR1. Moreover, TNFa and IL-1β significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models. Furthermore, TNFa and IFNγ act synergistically to induce expression of the major coreceptors for HIV infection, CXCR4 and CCR5, at both the mRNA and protein levels in human and simian astrocytes, whereas CCR3 expression was not affected by cytokine treatment. Finally, TNFα/IFNγ was the most significant cytokine combination in leading to a pronounced upregulation in a comparable, time-dependent manner of the production of chemokines IP-10/CXCL10, RANTES/CCL5, MIG/CXCL9, MCP-1/CCL2, and IL-8/CXCL8. In , these data suggest that astrocytes serve as an important source of chemokines under the dependence of a complex cytokine regulation, and TNFa and IFNγ are important modulators of chemokines and chemokine receptor expression in human as well as simian astrocytes. Finally, with the conditions we used, there was no difference between species or age of tissue.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Croitoru Lamoury, Juliana" sort="Croitoru Lamoury, Juliana" uniqKey="Croitoru Lamoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name>
</noRegion>
<name sortKey="Boussin, Francois D" sort="Boussin, Francois D" uniqKey="Boussin F" first="Francois D." last="Boussin">Francois D. Boussin</name>
<name sortKey="Cheret, Arnaud" sort="Cheret, Arnaud" uniqKey="Cheret A" first="Arnaud" last="Cheret">Arnaud Cheret</name>
<name sortKey="Dormont, Dominique" sort="Dormont, Dominique" uniqKey="Dormont D" first="Dominique" last="Dormont">Dominique Dormont</name>
<name sortKey="Gigout, Laure I" sort="Gigout, Laure I" uniqKey="Gigout L" first="Laure I." last="Gigout">Laure I. Gigout</name>
<name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name>
<name sortKey="Mognetti, Barbara" sort="Mognetti, Barbara" uniqKey="Mognetti B" first="Barbara" last="Mognetti">Barbara Mognetti</name>
<name sortKey="Vaslin, Bruno" sort="Vaslin, Bruno" uniqKey="Vaslin B" first="Bruno" last="Vaslin">Bruno Vaslin</name>
</country>
<country name="Australie"><noRegion><name sortKey="Croitoru Lamoury, Juliana" sort="Croitoru Lamoury, Juliana" uniqKey="Croitoru Lamoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name>
</noRegion>
<name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name>
<name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name>
<name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name>
</country>
</tree>
</affiliations>
</record>

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Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and ccr5 modulation

Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and ccr5 modulation

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